Fri Mar 01 2024

84 articles - From Friday Feb 23 2024 to Friday Mar 01 2024

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Am J Gastroenterol

Insurance Companies' Poor Adherence to Guidelines for Moderate to Severe Ulcerative Colitis/Crohn's Disease Management.

Nearly every insurance company required failure of steroids and immunomodulators before biologic therapy. Further work is required to improve patient access to standard of care treatment.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

AGA Clinical Practice Update on High-Quality Upper Endoscopy: Expert Review.

BEST PRACTICE ADVICE 9: Endoscopists should document whether subsequent surveillance endoscopy is indicated and, if so, provide appropriate surveillance intervals. If the determination of surveillance is contingent on histopathology results, then endoscopists should document that surveillance intervals will be suggested after results are available.

Pubmed   Journal   ReadQx 

Gastroenterology

AGA Clinical Practice Guideline on Fecal Microbiota-Based Therapies for Select Gastrointestinal Diseases.

Fecal microbiota-based therapies are effective therapy to prevent recurrent C difficile in select patients. Conventional fecal microbiota transplant is an adjuvant treatment for select adults hospitalized with severe or fulminant C difficile infection not responding to standard of care antibiotics. Fecal microbiota transplant cannot yet be recommended in other gastrointestinal conditions.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Physician perceptions on the current and future impact of artificial intelligence to the field of gastroenterology.

Gastroenterologists have an overall positive perception regarding the use of AI in clinical practice but voiced concerns regarding its technical aspects and coverage of costs associated with implementation. Further education on the clinical use of AI applications with understanding of the advantages and limitations appears to be valuable in promoting adoption.

Pubmed   Journal   ReadQx 


Meta-analysis

meta-analyses and systematic reviews

Am J Gastroenterol

Adenomas and Sessile Serrated Lesions in 45-49- Year-Old Individuals Undergoing Colonoscopy: A Systematic Review and Meta-Analysis.

Pubmed   Journal   ReadQx 

EUS-Guided Vs. ERCP-Guided Biliary Drainage as Primary Approach to Malignant Distal Biliary Obstruction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

EUS-BD is an efficient and safe alternative to ERCP in MDBO. An almost nonexistent risk of procedure-related pancreatitis, lower procedure time, and ease of use makes this an attractive primary approach to biliary decompression in centers with expertise.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Antibiotic exposure and risk of new-onset inflammatory bowel disease: a systematic review and dose-response meta-analysis.

Antibiotic exposure was significantly associated with an increased risk of new-onset IBD, and a positive nonlinear dose-response relationship was observed. Antibiotic stewardship may be important for reducing IBD risk.

Pubmed   Journal   ReadQx 

GLOBAL PREVALENCE OF PANCREATIC CYSTIC LESIONS IN THE GENERAL POPULATION ON MAGNETIC RESONANCE IMAGING: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Subgroup analysis showed higher PCL prevalence when imaging findings were confirmed by independent radiologist(s) (25%; 95%CI 16-33) than when chart review alone was used (5%; 95%CI 4-7; p<0.01). There was no independent association of PCL prevalence with geographic location (Europe, North America or Asia), MRI indication (screening vs evaluation of non-pancreatic pathology), enrollment period, sample size, magnet strength (1.5 vs 3 tesla), and MRI sequence (MRCP vs no MRCP) CONCLUSION: In this systematic review, the global prevalence of PCLs using a highly sensitive non-invasive imaging modality ranged between 13% to 18%.

Pubmed   Journal   ReadQx 

Endosc Int Open

Endoscopic full-thickness plication for the treatment of gastroesophageal reflux disease: A systematic review and meta-analysis.

The findings from our study reveal that EFTP is a safe and effective treatment for GERD patients who have not responded adequately to conventional therapies. Given its minimally invasive nature, effectiveness, and limited adverse effects, EFTP emerges as a compelling alternative to conventional surgical procedures.

Pubmed   Journal   ReadQx   PMC


Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Branched-chain amino acid supplementation does not improve measures of sarcopenia in cirrhosis: results of a randomised controlled trial.

BCAA supplementation did not improve measures of muscle strength, mass or performance or physical frailty compared to a whey protein supplement in a randomised controlled setting. ACTRN12618000802202.

Pubmed   Journal   ReadQx 

CAMP-B score predicts the risk of hepatocellular carcinoma in patients with chronic hepatitis B after HBsAg seroclearance.

The CAMP-B score (cirrhosis, age ≥50 years, male sex and platelet count <150,000/mm 3 /L) was significantly associated with HCC development after HBsAg seroclearance. CAMP-B score can be easily implemented in real-world clinical practice and helps stratify HCC risk in patients with CHB following HBsAg seroclearance.

Pubmed   Journal   ReadQx 

Evaluation of potential hepatic recompensation criteria in patients with PBC and decompensated cirrhosis.

Patients with PBC and decompensated cirrhosis may achieve hepatic recompensation under UDCA therapy. However, since liver-related complications still occur after recompensation, patients should remain under close follow-up.

Pubmed   Journal   ReadQx 

High-dose proton pump inhibitor treatment is associated with a higher mortality in cirrhotic patients: A multicentre study.

The use of high-dose PPI was independently associated with increased risks of mortality and cirrhotic complications.

Pubmed   Journal   ReadQx 

Impact of inflammatory bowel disease on the risk of acute coronary syndrome: A Swedish Nationwide Cohort Study.

In this contemporary cohort of patients with IBD, exposed to modern IBD care, there was an increased risk for ACS compared with individuals from the general population.

Pubmed   Journal   ReadQx 

Persistently high HBsAg levels during HBeAg-seropositive stage predict lower risk of hepatocellular carcinoma in chronic hepatitis B patients.

Patients with persistently high HBsAg levels during HBeAg-seropositive stage represent a unique population with low risk of HCC development.

Pubmed   Journal   ReadQx 

Terlipressin therapy is associated with increased risk of colonisation with multidrug-resistant bacteria in patients with decompensated cirrhosis.

Our study reports an increased risk of MDRO colonisation in patients with AD or ACLF, who recently received terlipressin therapy, while other commonly prescribed non-antibiotic co-medications had negligible influence. Future prospective trials are needed to confirm these results.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Outcomes of high-grade immune checkpoint inhibitor hepatitis in hospitalized and non-hospitalized patients.

Hospitalization of patients with high-grade ICI hepatitis was not associated with faster hepatitis resolution and did not affect mortality. Routine hospitalization may not be necessary in al patients with high-grade ICI hepatitis and CTCAE criteria may overestimate severity of liver injury.

Pubmed   Journal   ReadQx 

Endosc Int Open

Assessment of pancreatic ductal stone density on non-contrast computed tomography for predicting the outcome of extracorporeal shock wave lithotripsy.

The SD is a significant predictor of ESWL success followed by ductal clearance at ERCP, and <1106.5 HU is a predictor of good candidates for ESWL therapy.

Pubmed   Journal   ReadQx 

Association of short-course antimicrobial therapy and bacterial resistance in acute cholangitis: Retrospective cohort study.

In acute cholangitis, the administration of antimicrobials within 3 days of ERCP may suppress the development of resistant bacteria.

Pubmed   Journal   ReadQx 

Comparison of diagnostic outcomes, safety, and cost of Franseen-tip 19G versus 22G needles for endoscopic ultrasound-guided liver biopsies.

The Franseen-tip 19G outperforms 22G with a significantly lower fragmentation rate, longer AL, LIC, and a higher number of CPT with a marginal increase in the procedure cost, without any difference in diagnostic yield and safety.

Pubmed   Journal   ReadQx 

Evaluation of exclusive internal endoscopic drainage for complex biloma with transluminal and transpapillary stenting.

If both techniques can be performed, EUS-TBD should be considered because of the short times for the procedure, hospital stay. and biloma resolution.

Pubmed   Journal   ReadQx 

Interactive training with a novel simulation model for upper gastrointestinal endoscopic hemostasis improves trainee technique and confidence.

Our study demonstrates the potential of our simulation-based training model as a valuable tool for improving technical skills and confidence in trainees learning to perform endoscopic hemostasis.

Pubmed   Journal   ReadQx 

Practice patterns and outcomes of endoscopic sleeve gastroplasty based on provider specialty.

Data from a large US cohort show significant and sustained weight loss with ESG and an excellent safety profile in both bariatric surgery and gastroenterology practices, supporting the scalability of the procedure across practices in a multidisciplinary setting.

Pubmed   Journal   ReadQx   PMC

Safety and efficacy of early versus late removal of LAMS for pancreatic fluid collections.

Early LAMS removal (< 4 weeks) did not prevent AEs but did lead to increased clinical failure.

Pubmed   Journal   ReadQx 

Same-session endoscopic diagnosis and symptom palliation in pancreato-biliary malignancies: Clinical impact of rapid on-site evaluation (ROSE).

g. uncovered SEMS or therapeutic EUS), potentially reducing hospitalization and time to oncological treatments.

Pubmed   Journal   ReadQx 

The Bethesda ERCP Skills Assessment Tool (BESAT) can reliably differentiate endoscopists of different experience levels.

Study findings demonstrate that the BESAT, a video-based ERCP skill assessment tool, has high inter-rater reliability and has discriminative validity in differentiating novice from expert ERCP skill. Further investigations are needed to determine the role of video-based assessment in improving trainee learning curves and patient outcomes.

Pubmed   Journal   ReadQx 

Endoscopy

Artificial intelligence-assisted system for the assessment of Forrest classification of peptic ulcer bleeding: a multicenter diagnostic study.

The DCNN system for the assessment of the Forrest classification of PUB showed satisfactory diagnostic performance, which was slightly superior to that of senior endoscopists. It could therefore effectively assist junior endoscopists in making such diagnoses during gastroscopy.

Pubmed   Journal   ReadQx 

Multicenter Prospective Randomized Controlled Clinical Trial Comparing the Pocket-Creation Method with and without Single Clip Traction of Colonic Endoscopic Submucosal Dissection.

ESD facilitated by the novel PCM-CT appears to be significantly faster. Additionally, both PCM-CT and PCM achieved high R0 resection rate.

Pubmed   Journal   ReadQx 

Gastroenterology

Efficacy and findings of a blinded randomized reintroduction phase for the low FODMAP diet in Irritable Bowel Syndrome.

We confirmed the significant benefit of the low-FODMAP diet in tertiary care IBS. A blinded reintroduction revealed a personalized pattern of symptom recurrence, with fructans and mannitol as the most prevalent, and allows the most objective identification of individual FODMAP-triggers; Clinicaltrial.gov number NCT04373304.

Pubmed   Journal   ReadQx 

TGF-β1 Induced SOX18 Elevation Promotes Hepatocellular Carcinoma Progression and Metastasis through Transcriptionally Upregulating PD-L1 and CXCL12.

SOX18 promoted the accumulation of immunosuppressive TAMs and Tregs in microenvironment by transactivating CXCL12 and PD-L1. CXCR4 inhibitor or TGFβR1 inhibitor in synergy with anti-PD-L1 represented a promising combination strategy to suppress HCC progression and metastasis.

Pubmed   Journal   ReadQx 

Gut

HBV integrations reshaping genomic structures promote hepatocellular carcinoma.

HBV integrations extensively reshape genomic structures and promote hepatocarcinogenesis (graphical abstract), which may occur early in a patient's life.

Pubmed   Journal   ReadQx 

MASH Resolution Index: development and validation of a non-invasive score to detect histological resolution of MASH.

The MASH Resolution Index may be a useful score to non-invasively identify MASH resolution.

Pubmed   Journal   ReadQx 

Hepatology

Endothelial YAP/TEAD1-CXCL17 signaling recruits myeloid-derived suppressor cells against liver ischemia-reperfusion injury.

Endothelial YAP/TEAD1-CXCL17 signaling recruited MDSCs to attenuate liver IRI, providing evidence of a therapeutic potential for managing IRI in liver surgery.

Pubmed   Journal   ReadQx 

Integrative transcriptomic and genomic analyses unveil the IFI16 variants and expression as a MASLD progression markers.

This study unveils a comprehensive understanding of MASLD progression through transcriptomic classification, highlighting the crucial roles of IFI16 variants. Targeting the IFI16-PYCARD-CASP1 pathway may pave the way for the development of novel diagnostics and therapeutics for MASLD.

Pubmed   Journal   ReadQx 

J Hepatol

CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma.

Activation of the CRKL/β-catenin/VEGFα and CXCL1 axis is a critical obstacle to successful anti-PD-1 therapy. Therefore, CRKL inhibitors combined with anti-PD-1 may be developed for the treatment of HCC. Impact and implications Here, we found CRKL was overexpressed in anti-PD-1 resistant HCC and CRKL upregulation promotes anti-PD-1 resistance in HCC. We identified that CRKL/β-catenin/VEGFα and CXCL1 axis upregulation contributes to anti-PD-1 tolerance through promoting tumor-associated neutrophils (TANs) infiltration. These findings support the strategy of bevacizumab-based ICIs combination therapy, and CRKL inhibitors combined with anti-PD-1 therapy may be developed for the treatment of HCC.

Pubmed   Journal   ReadQx 

Single cell landscape of functionally cured chronic hepatitis B patients reveals activation of innate and altered CD4-CTL-driven adaptive immunity.

Our study provides conceptually novel insights into the immuno-pathological control of HBV cure, and opens exciting new avenues for clinical management, biomarker discovery and therapeutic interventions. We believe that the discoveries from this study, as it relates to the activation of an innate and altered immune response that may facilitate sustained, low-grade inflammation, may have broader implications in the resolution of chronic viral hepatitis.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: Towards optimal thiopurine therapy for inflammatory bowel disease.

Pubmed   Journal   ReadQx 

Editorial: Updated epidemiology of steatotic liver disease in people with HIV in the United States.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Approaching Digestive Health Care in Transgender and Gender-Diverse Communities.

Pubmed   Journal   ReadQx 

Blue Notes.

Pubmed   Journal   ReadQx 


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Green Endoscopy.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Assessing Diagnostic Performance of Modifications to the Rome IV Criteria for Irritable Bowel Syndrome.

Pubmed   Journal   ReadQx 

MALT lymphoma of the esophagus.

Pubmed   Journal   ReadQx 

PHOSPHATIDYLETHANOL DETECTS OCCULT HEAVY ALCOHOL USE IN PATIENTS WITH ACUTE AND CHRONIC PANCREATITIS.

Pubmed   Journal   ReadQx 

Serum Ammonia Levels Do Not Correlate With Overt Hepatic Encephalopathy Severity in Hospitalized Patients With Cirrhosis.

Pubmed   Journal   ReadQx 

Endosc Int Open

A stent-removing thread sticking adjacent to the duodenoscope elevator identified using the double-scope technique.

Pubmed   Journal   ReadQx 

Emergency digital cholangioscopy-assisted electrohydraulic lithotripsy for basket impaction with an entrapped bile duct stone.

Pubmed   Journal   ReadQx 

Endoscopy

A new endoscopic solution for rectal anastomotic atresia: Contrast agent-guided precision dilation.

Pubmed   Journal   ReadQx   PMC

A rare case of endoscopic full-thickness resection of a laterally spreading tumor at the anastomotic site of appendectomy.

Pubmed   Journal   ReadQx   PMC

Advancing the Practice of Gastrointestinal Endoscopy Through Research.

Pubmed   Journal   ReadQx 

An unusual pancreas divisum intraductal papillary mucinous neoplasm diagnosed by pancreatoscopy-assisted endoscopic ultrasonography rendezvous procedure.

Pubmed   Journal   ReadQx   PMC

Biliary ascariasis: extraction.

Pubmed   Journal   ReadQx   PMC

Cholangioscopy findings of biliary candidiasis post-liver transplantation.

Pubmed   Journal   ReadQx   PMC

Endoscopic hand-suturing for postoperative suture failure.

Pubmed   Journal   ReadQx   PMC

Endoscopic radial incision of a congenital antral web in a child.

Pubmed   Journal   ReadQx   PMC

Endoscopic removal of a whole ascaris from the colonic lumen.

Pubmed   Journal   ReadQx   PMC

Endoscopy E-Videos - recently published.

Pubmed   Journal   ReadQx 

Gallstone sigmoid obstruction treated with electrohydraulic lithotripsy.

Pubmed   Journal   ReadQx   PMC

Hepatic fascioliasis: a rare case of "fake" biliary gallstones.

Pubmed   Journal   ReadQx   PMC

Innovations for colonic endoscopic submucosal dissection: combination of the latest game changers.

Pubmed   Journal   ReadQx 

Mucosal snare resection-endoscopic submucosal excavation: a novel technology.

Pubmed   Journal   ReadQx   PMC

Needle-free technique for guidewire manipulation during endoscopic ultrasound-guided pancreatic duct drainage.

Pubmed   Journal   ReadQx   PMC

Successful closure of a detached muscle layer during gastric endoscopic submucosal dissection with fibrosis using clips with the use of polyglycolic acid sheets and fibrin glue.

Pubmed   Journal   ReadQx   PMC

Underwater coagulation using hybrid knife in peroral endoscopic myotomy for achalasia.

Pubmed   Journal   ReadQx   PMC

Unraveling the conumdrum: innovative technique to remove the stent from the displaced pancreatic duct in stenosis.

Pubmed   Journal   ReadQx   PMC

Use of adaptive traction for endoscopic submucosal dissection when using a bipolar knife for cardiological reasons.

Pubmed   Journal   ReadQx   PMC

Gastroenterology

Approaching Digestive Health Care in Transgender and Gender-Diverse Communities.

Pubmed   Journal   ReadQx 

Diagnostic and Prognostic Biomarkers of Chronic Pancreatitis: A Conceptual Framework Based on PRoBE Design.

Pubmed   Journal   ReadQx 

In search of the best second-line therapy for Primary Biliary Cholangitis.

Pubmed   Journal   ReadQx 

When aspirin causes damage - microbes modulate the host to restore gut homeostasis.

Pubmed   Journal   ReadQx 

Gut

New AI model for neoplasia detection and characterisation in inflammatory bowel disease.

Pubmed   Journal   ReadQx 

Recurrent intestinal ulcers and perforations complicated with pigmentation.

Pubmed   Journal   ReadQx 

Role of patient and staff mobility in scope 3 emissions in GI endoscopy.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: Towards optimal thiopurine therapy for inflammatory bowel disease-authors' reply.

Pubmed   Journal   ReadQx 

Editorial: Updated epidemiology of steatotic liver disease in people with HIV in the United States-Authors' reply.

Pubmed   Journal   ReadQx 

Letter: Severe underweight and sarcopenia in decompensated cirrhosis are associated with high FGF21 levels-authors' reply.

Pubmed   Journal   ReadQx 

Letter: Severe underweight and sarcopenia in decompensated cirrhosis are associated with high FGF21 levels.

Pubmed   Journal   ReadQx 

Gut

Cause of death by fibrosis stage in 959 patients with biopsy-proven NAFLD.

Pubmed   Journal   ReadQx 

J Hepatol

"Autoimmune Hepatitis: Azathioprine or Mycophenolate Mofetil for inducing remission?"

Pubmed   Journal   ReadQx 

An in-depth exploration of difference and similarity between NAFLD and MASLD.

Pubmed   Journal   ReadQx 

Letter: Changing from NAFLD to MASLD: The Implications for health related quality of life data.

Pubmed   Journal   ReadQx 

Potential augmentation of terlipressin antidiuretic effects by gabapentinoids.

Pubmed   Journal   ReadQx 

Should MMF treatment be the first-line therapy in autoimmune hepatitis?

Pubmed   Journal   ReadQx 

The Transition from NAFLD to MASLD and Its Impact on Clinical Practice and Outcomes.

Pubmed   Journal   ReadQx